[ArkPhaze]

Dim OpenSelected As String
OpenSelected = "C:\" & TextBox1.Text.ToString
System.Diagnostics.Process.Start(OpenSelected)

Figured it out. I was trying to open the file all wrong. Above is the code I wound up using.

Coder-San - Thank you for tellg me that it triggering was a factor it all sort of fell into place after you said that.

That still looks wrong to me. Why limit it to C:\? Now if they want to access Z: or X: it would append to the "C:\" making an invalid path. Never hardcode any filepath values like that directly from "C:\"